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Sunday, August 9, 2020 | History

1 edition of Development of the rodent as a model system of aging found in the catalog.

Development of the rodent as a model system of aging

Development of the rodent as a model system of aging

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  • 3 Currently reading

Published by National Institute of Child Health and Human Development; [for sale by the Supt. of Docs., U.S. Govt. Print. Off., Washington in Bethesda, Md .
Written in English

    Subjects:
  • Aging.,
  • Rodents as laboratory animals.,
  • Rodents -- Physiology.,
  • Models, Biological.,
  • Aging.,
  • Research.

  • Edition Notes

    StatementDon C. Gibson, scientific editor.
    SeriesDHEW publication no. (NIH) 72-121, DHEW publication -- no. (NIH) 72-121.
    ContributionsGibson, Don C., National Institute of Child Health and Human Development (U.S.), New Orleans Conference on the Rodent as a Model System for Research in Aging (1970).
    The Physical Object
    Pagination1 v.
    ID Numbers
    Open LibraryOL14111433M

    Such complexities make the choice of a suitable stress research model both a difficult, and vital one. While some mechanisms, e.g. activation agents of specific adrenal or pituitary cell types, may be elucidated in cell culture, a whole-system model is required in order to assess the net effect of any stressor to these by: 5.   Aging increases the risk of abrupt declines in cognitive function after an event that triggers immune system activation (e.g. surgery, infection, or injury). This phenomenon is poorly understood, but rodent models may provide clues. We have previously shown that aging (mo-old) FxBN rats generally do not show significant physical or cognitive by: 2.

    The recent advances in developmental biology described in Chapter 6 have established the central importance of a small number of highly conserved signal transduction pathways that mediate cell interactions crucial for animal physiology, reproduction, and development. It seems likely that many developmental toxicants might affect development by acting on those pathways. Experimental Neurology, a Journal of Neuroscience Research, publishes original research in neuroscience with a particular emphasis on novel findings in neural development, regeneration, plasticity and journal has focused on research concerning basic mechanisms underlying neurological disorders.. US National Institutes of Health (NIH) voluntary posting ("Public Access") policy.

      In the present paper, we presented just a few of the barriers to the development of a valid rodent model of SAD. These barriers include the use of mutant mouse models of the familial version of this disorder that do not represent the disease state in humans with this rare affliction let alone the masses of aged patients with by:   Huntington’s disease is associated with cell death in the basal ganglia, part of which is pictured here. Huntington’s disease (HD) is a fatal, inherited disorder that destroys brain cells in a region of the brain involved in motor control. Caused by a mutation in the huntingtin gene, the disease impairs brain cells’ ability to function.


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Development of the rodent as a model system of aging Download PDF EPUB FB2

Get this from a library. Development of the rodent as a model system of aging. [Don C Gibson; National Institute on Aging.; National Institutes of Health (U.S.);]. Get this from a library. Development of the rodent as a model system of aging.

Don C. Gibson, scientific editor. [Don C Gibson; National Institute of Child Health and Human Development (U.S.);] -- Describes the activities of one day, from dawn to dusk, in the life of a roadrunner living in the desert. The development of osteoporosis in older men is mainly associated a model of aging in which human dermal fibroblasts were TH and Development of the Auditory System.

Experimental rodent studies have indicated that TH plays a key role in the maturation of many tissues within the auditory system during a critical period that. Materials drawn extensively from presentations at the New Orleans Conference on the Rodent as a Model System for Research in es bibliographical 2.

Edited by D. Gibson, R. Adelman and C. of access: InternetAuthor: Don C.#N# ed. Gibson. Development of the rodent as a model system of aging: Book II / By Caleb Finch, Richard C.

Adelman and Don C. Gibson. Abstract. Includes bibliographical references and of. Taken together, these data demonstrate that: (1) choosing an age of rodent relevant to the human disease being studied can have a critical impact on the performance of the model; (2) the age of rodent is often based on practical considerations or convention; and (3) the age of rodent reported as ‘adult’ is inconsistent between studies or Cited by: The basis for selection and study of rodent model systems.

In: Gibson DC, ed. Development of the rodent as a model system of aging. Washington, DC: DHEW publication no. (NIH), ; 4 Gibson DC, Adelman RC, Finch C, eds.

Development of the rodent as a model system of aging, book by: 3. Models of Immune Aging Sex and the aging immune system Rodent Models of Ovarian Failure Role of Sex and Aging in Mucosal Health Leydig Cell Development and Aging in the Brown Norway Rat: Mechanisms and Consequences Models of aging Kidney: Implications on kidney health and disease Format: NOOK Book (Ebook).

Introduction. Alzheimer's disease (AD) is an insidious, devastating, aging-related disease that has debilitating effects on cognition. AD is truly a plight of aging, with ~10 and ~40% of people over the age of 65 respectively, being affected (, ; Mormino, ).It is estimated that there are currently five million cases of AD in the United States and ~20–30 million cases Cited by: New Orleans Conference on the Rodent as a Model System for Research in Aging,() Title(s): Development of the rodent as a model system of aging.

Don C. Gibson, scientific editor. Country of Publication: United States Publisher: Bethesda, Md., National Institute of Child Health and Human Development; [for sale by the Supt.

of Docs., U. Abstract. A number of excellent review articles have examined the various physiological roles of taurine in adult and developing organi 20, A conclusion that can be drawn from these various reviews is that there is a dearth of information on the role of taurine in aging and by: Chapter Sex and the aging immune system Chapter Rodent Models of Ovarian Failure Chapter ROLE OF SEX AND AGING IN MUCOSAL HEALTH Chapter Leydig Cell Development and Aging in the Brown Norway Rat: Mechanisms and Consequences Chapter Models of aging Kidney: Implications on kidney health and disease Chapter Model organisms are drawn from all three domains of life, as well as most widely studied prokaryotic model organism is Escherichia coli (E.

coli), which has been intensively investigated for over 60 is a common, gram-negative gut bacterium which can be grown and cultured easily and inexpensively in a laboratory setting.

It is the most widely used organism in molecular. Unfortunately, this book can't be printed from the OpenBook.

If you need to print pages from this book, we recommend downloading it as a PDF. Visit to get more information about this book, to buy it in print, or to download it as a free PDF. Russell ES () Genetic consideration in the selection of rodent species and strains for research in aging.

In: Gibson DC (ed) Development of the Rodent as a Model System of Aging, (DHEW publication No. NIH 72– U.S. Government Printing Office, Washington, DC, pp 33–53 Google ScholarAuthor: Richard L.

Sprott. A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Aging Cell is a bi-monthly peer-reviewed, open access journal that aims to publish the highest quality, innovative research addressing fundamental issues in the biology of aging.

We are seeking applications from the Anatomical Society Membership for the /20 round (student start date 1st October ) Application details can be found here.

An important aging related project in Dr. Gunjan’s lab is to evaluate the role of individual histone genes and rDNA metabolism in aging using the budding yeast as a model system. Overall, Dr. Gunjan’s research will improve our understanding of the basic mechanisms underlying cancer and cellular aging.

Updated daily. Explore all research articles, conference papers, preprints and more on RODENT BEHAVIOR. Find methods information, sources, references or conduct a. Use the NIA Research Resources database to find NIA-supported scientific resources, datasets, informatics resources, and more.

Search by keyword, resource type, or NIA Division or IRP. With 2, participants, the ACTIVE Study is the largest study on cognitive training ever performed. Funded by the National Institutes of Health and led by. This particular strain of mouse is really an ideal rodent model for studying aging, as it ages in much the same way we do – which can help translate research to us.

The researchers demonstrated that diet plays a key role in the composition of the gut microbiome and that changes to diet can cause very rapid alterations to the populations of. The rodent model of delirium described in this study could inform future research to understand how surgery, infection, and injury -- factors that activate the immune system --.

Sporadic Alzheimer's disease (AD) is the most prevalent form of age-related dementia. As such, great effort has been put forth to investigate the etiology, progression, and underlying mechanisms of the disease.

Countless studies have been conducted, however, the details of this disease remain largely unknown. Rodent models provide opportunities to investigate certain aspects of AD that cannot Cited by: